Vilazodone is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Vilazodone is used to treat major depressive disorder (MDD). Do not use Vilazodone if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine, or if you have had a methylene blue injection.